Name and dosage form
Urea Plus 5% Cream, Metasense®
75 g
Uses
A moisturizing cream for dry skin that helps reduce roughness and restore the skin barrier.
Active ingredients
Urea, Hyaluronic Acid, L-Arginine, Glycine, Panthenol, Vitamin E
Therapeutic effects
Helps hydrate the skin and retain moisture, reduces dryness and mild flaking, and improves skin softness and smoothness.
How to use
Apply to clean, dry skin once or twice daily, or as directed by a physician. Massage gently until fully absorbed.
Pharmacology and mechanism of action
Urea is a naturally occurring component of the skin and an essential constituent of the Natural Moisturizing Factor (NMF). It possesses hygroscopic properties, enabling it to attract and retain water within the stratum corneum. In addition to its moisturizing effect, urea exhibits mild keratolytic activity at a concentration of 5%, helping to soften the outermost layer of dead skin cells and reduce skin roughness
The other ingredients in this formulation support skin hydration and barrier function through complementary mechanisms:
- Hyaluronic Acid: A powerful humectant that attracts and retains large amounts of water, helping to improve skin hydration, elasticity, and smoothness.
- L-Arginine and Glycine: Amino acids that contribute to skin hydration, support the skin barrier, and promote collagen synthesis.
- Panthenol (Provitamin B5): Helps strengthen the skin barrier, improves skin softness, and reduces transepidermal water loss (TEWL) by increasing moisture retention in the stratum corneum.
- Vitamin E: A potent lipid-soluble antioxidant that helps protect the skin from oxidative stress and environmental aggressors, including UV-induced free radicals.
Notes and warnings
- For external use only. Do not apply to the eyes or mucous membranes.
- Do not use if you are allergic to urea or any other ingredient in this product.
- Do not apply to irritated skin, open wounds, or infected lesions.
- If redness, itching, or persistent irritation occurs, discontinue use and consult a physician if necessary.
- A mild burning or stinging sensation may occur upon initial application and is usually temporary. If it persists or worsens, discontinue use and consult a physician.
Maintenance
Store below 30°C, protected from direct sunlight.
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